Mucilin Sachets 40s - Isphagula Husk Fibre sachets

Contents
Refined mucilloid of ispaghula seed (ispaghula husk).
Description
Each sachet (5 gm) contains Refined Mucilloid of Ispaghula Seed (Ispaghula Husk) 2.45 g.

Action

Pharmacology: Pharmacodynamics: Ispaghula husk is capable of absorbing up to 40 times its own weight in water. Ispaghula husk consists 85% water-soluble fiber, it is partly fermentable and acts by hydration in the bowel. The pharmacological effects, gut motility and transit rate can be modified by the Ispaghula husk through mechanical stimulation of the gut wall depending on the increase in intestinal bulk by water and the decrease in viscosity of the luminal contents

Pharmacokinetics: Absorption: The material hydrates and swells to form a mucilage because it is only partially solubilised. Less than 10% of the mucilage gets hydrolysed in the stomach.

Progress of action: Ispaghula husk usually acts within 12 to 24 hours after single administration.
Elimination: Human intestinal flora in the large intestine degrades the polysaccharides.

Indications/Uses
For the treatment of habitual constipation; in conditions in which easy defaecation with soft stools is desirable, e.g. in cases of painful defaecation after rectal or anal surgery, anal fissures and haemorrhoids; in patients to whom an increased daily fiber intake may be advisable e.g. as an adjuvant in constipation predominant irritable bowel syndrome, as an adjuvant to diet in hypercholesterolemia.

Dosage/Direction for Use
For the treatment of habitual constipation and in conditions in which easy defaecation with soft stools is desirable, e.g. in cases of painful defaecation after rectal or anal surgery, anal fissures and haemorrhoids.

Adolescents over 12 years of age, adults, elderly: 7-11 g in 1-3 doses daily.
Children from 6 to 12 years of age: Half to two-thirds of the adult dose (3-8 g) daily.
In patients to whom an increased daily fibre intake may be advisable e.g. as an adjuvant in constipation predominant irritable bowel syndrome, as an adjuvant to diet in hypercholesterolemia: Adolescents over 12 years of age, adults, elderly: 7-20 g in 1-3 doses daily.

Administration: Mix one sachet or 2 teaspoonfuls of Mucilin with 150 mL of cool water, milk, fruit juice or other drinking liquid; stir briskly and drink immediately; followed by an additional glass of water or other drinking liquid.

Overdosage

Overdose with Ispaghula husk may cause abdominal discomfort and flatulence and even intestinal obstruction. An adequate fluid intake should be maintained and management should be symptomatic.

Contraindications
Ispaghula husk is not to be used by patients with a sudden change in bowel habit that persists for more than 2 weeks, undiagnosed rectal bleeding and failure to defaecate following the use of a laxative.

Ispaghula husk is not to be used by patients suffering from abnormal constrictions in the gastro-intestinal tract, with diseases of the eosophagus and cardia, potential or existing intestinal blockage (ileus)