Description Each tablet of Heptral 200/400 contains ademetionine or S-adenosyl-L-methionine 200 mg or 400 mg, respectively. S-adenosyl-L-methionine (SAMe) is a derivative of the amino acid methionine and is a naturally-occurring substance distributed throughout the human body. It is present in all living cells and takes part in many biochemical reactions in the body and it is important for a large number of metabolic pathways in the body. Ademetionine is not easily available from typical dietary sources. Excipients/Inactive Ingredients: Microcrystalline Cellulose, Mannitol, Carboxymethylstarch sodium salt, Colloidal sillica, anhydrous, Glycerol behenate, Magnesium stearate, Methacrylic acid copolymer, Titanium dioxide, Talc, Triethyl citrate, FD&C yellow No 5. Indications/Uses Heptral 200/400 is used in adults for: Supporting healthy liver function and reduction of tiredness and fatigue; Providing general liver tonic effect; supporting healthy mood balance. Dosage/Direction for Use Adults: Take 1 or 2 tablets per day or as directed by the healthcare professional. Benefits are most likely evident after 7-14 days and are maintained with continued use. The maximum daily dose of 1600 mg/day (4 tablets of 400 mg or 8 tablets of 200 mg) should not be exceeded. Heptral 200/400 should be swallowed whole and not chewed. For better absorption of the active ingredient and complete therapeutic effect, Heptral 200/400 should not be taken with meals.